Kino is the main protagonist in the series and travels to different countries with her talking motorcycle Hermes, discovering their cultures and people. In the anime, Kino's gender is ambiguous in the beginning, but is later confirmed to be female in the fourth episode, in which she first meets Hermes and borrows the name Kino from another traveler. She is skilled in combat, carrying both guns and knives, and is accustomed to life as a traveler. To those she meets, she is invariably polite and answers questions directly. Her gender is not initially apparent to the viewer, because she is almost flat chested (despite being in her mid-teens), heavily armed, and dresses in baggy masculine motorcycle gear, as well as her usage of a masculine pronoun to refer to herself.

The second generation sharpener Melk. She is the adoptive daughter of Melk the first. She doesn't recognize her own sharpening skills, but Melk the first told Toriko they're both on the same level of sharpening ability. She tought her father that was disappeared for six years died in the Heavy Hole, but it's revealed he was trying to forge a knife for preparing Bishikushin Acacia's Full-Course salad "Air". After Toriko returns from the Heavy Hole with the Melk Stardust, she makes Komatsu a new knife using his broken knife and the Deroth Dragon's fang.