The twisted quarterback of the Devil Bats, who is more complex than his devilish face and personality may suggest. He carries multiple firearms at all times and often pulls them out at random in order to threaten others in a comical flurry of bullets. Despite this front of a violent and dangerous hoodlum, Hiruma is a genius in maverick trick plays and mind games, both on and off the field. Along with Kurita and Musashi, he is the one of the founders of the Devil Bats. His skills as a quarterback are highly recognized, even by Shin, including making passes with incredibly high RPMs as well as executing extremely convincing play action fakes. Because he has worked with a poor defensive line in his earlier days on the team, he is very good at dodging and feinting incoming tacklers. His specialty off the field is a combination of blackmail and mind games along with a superior intellect, which has effectively allowed him to take control of all of Deimon High, including the faculty.

A 15 year-old teen who gets by robbing rich people's mansions. He's very intelligent and sharp, his strong point being his knowledge of mechanics. He is also a skilled shooter and likes to carry around a gun. Gareki distrusts people and isn't very sociable, stating that he hates associating with others. However, despite his arrogant and distant attitude, he does have a more caring side that he doesn't like showing, seeming to have a soft spot for smaller children and Nai. He originally thought to use Nai for his robbing schemes but later joins him to find Karoku. When Nai tells Gareki about Karoku knowing that they were together, Gareki realizes that Karoku wants to keep him away from Nai.

Illegitimate son of Cardinal Rodrigo Borgia, his soul was sold to the Devil by his father. Ever since his birth, he has been surrounded by evil spirits, who protect him from those who would harm him physically. The birth of Cesare was ominous: his pregnant mother, Nachine, had been struck by lightning and forced to deliver the baby earlier. After she gave birth to Cesare, she said that she felt like the lightning was meant for her and she heard a voice announcing that "the pact has been sealed". When the nun carries the baby away, she sees a monstrous shadow and confronts Rodrigo about the baby. The Cardinal denies everything and leaves. Terrified of what had happened to her child, the mother decides to strangle him, but that moment she is pushed behind by the evil spirits that surrounded her son and a candle falls down, starting a fire from which only Cesare survived. The baby is then given into the care of Vannozza dei Cattanei, the Cardinal's new mistress, who has the power to banish the evil spirits.

The main protagonist of this story, Jio is a boy with great battle skill, great trust towards his friends and an ability to persevere, but he also has an obsession with money and is not soon to show his feelings, often hiding them or blaming other factors.
His dream is world domination, which other people often laugh at, calling it a child's dream until they see his abilities.
Jio started his life without friends, the people in his village forcing him to leave after the death of his only friend Jin's parents for which he was blamed. He was later trained in the wild by a wolf, known as Zero. However, after completing his training he was chased away again, giving him a chance to complete his dream.

Alchemy, science and knowledge-related technique Seiran is the Knight of the blue rose and is not often at school because he is mostly sick. When he is sick, Seiran stays by himself inside the greenhouse filled with roses, and ironically his illness may be an allergic reaction to roses, as he appears fine when he isn't around them. He specializes in "Alchemy" or rather "science". He is also very cute, cute enough to be a girl. He is the sacrificial rose that was made in the past to help seal the devil's seal. His memories and Kaede's memories are not real, so he plans to use his body to restore the seal. In chapter 11 he is saved from the seal. His rose is not found in nature, because they replace the Yellow Rose with the Blue Rose. But even so he cares a lot about Anís. Once he asks her if she would accept his love and when she does not get what he says, he changes the subject about the love potion thinking it might be too soon.