In the medical profession, there is a name spoken in hushed tones, of an unlicensed genius physician who can save lives — for a price. His name is Black Jack, and he is a dashing, moody figure, caped in black, a Harlock* of medicine, a man who lives by no rules other than his own — and the Hippocratic Oath. A man who would defy the will of God himself in the name of preserving life.

Black Jack is an underground surgeon, who, although he has no license, has God-Like skills which enable him to perform operations that are impossible for even the finest surgeons.

Charging millions for secret operations, Black Jack is a man who is alone and full of mystery, appearing in operating rooms to fulfill his tasks, and then disappearing.

And now... his biggest challenge... An extraordinary number of intellectual and athletic geniuses (the Super Humans) have the world caught in awe, wonder and excitement. However, little does anyone know about the hideous conspiracy lurking behind this phenomenon... Black Jack comes face to face with a lethal virus, which may endanger the very existence of mankind!

Sora kara Kita Kodomo covers the events of the same titled manga chapter 143.

Black Jack is approached by a defecting soldier and his wife with a plea to help their son, who is afflicted with a rare disease. Although it might already be too late for the boy, Black Jack is able to save the child. But at what cost?

People's search for better health never ends. That is one of the reasons the study of anatomy and medicine was born. And to keep the physicians in check, we have medical laws. Black Jack goes outside and beyond those laws. He's an unlicensed, genius surgeon, traveling around the globe to complete his masterpieces. In this series, entitled "The 4 Miracles of Life", we will witness Tezuka Osamu asking the everlasting question about life once again.

Black Jack is an unregistered doctor with a clouded, mysterious past. He works with his little assistant Pinoko (who has a massive crush on the doctor), dealing with medical cases not very well known, which can be strange, dangerous, or not known at all. But he is a genius, and can save almost any of his patients' life (as long as they have the money for it, that is), and is known to many around the world, especially to those of medicine and science. He's a man of science himself, and does not believe much until he has seen it, yet it is many times he is surprised by love and nature often overpowering the science he bases his life in.

The mega-corporate Daedalus Group is under attack by a small group of activists known as the Ghost of Icarus. While taking care of some of the victims of the bombing, Black Jack encounters Dr. Kiriko, also known as Death Incarnate, who just like him, asks his patients huge sums of money but instead of saving them, he offers them a painless death. When the activist group requests both doctors' collaboration, Black Jack finds himself caught in a spiral of life, death and treason while trying to save his patients' lives and avoid the breaking of a biological war that could destroy humanity.

Black Jack attempts to find out the conspiracy, of why he was involved in the bombfield accident that killed his mother, while he uncovers secrets of Organization and Project "Noir", which, his father and other famous doctors were involved in..