Yumehara Nozomi, a regular student, finds a magical book called the Dream Collet in the library and meets Coco and Nuts, two creatures from the Palmier Kingdom. They plead with Nozomi to restore their world, which has been destroyed by an organization called the Nightmares, by completing the Dream Collet and finding the 55 Pinkies to make any wish come true. Meanwhile, the Nightmares are moving into the real world. Once Nozomi agrees to help, Coco and Nuts transform her into the magical girl Cure Dream and turn four fellow students into her Pretty Cure team.

While Nozomi and her friends are enjoying themselves at Princess Land, an amusement park, Coco and Nuts have been abducted into the Mirror Kingdom. At the same time, Shadow is after the Dream Collet so that he can use the power of the Pinkies to rule the Mirror Kingdom. To prevent this from happening, Migirin and Hidarin, who are residents of the Mirror Kingdom, become allies with Pretty Cure to assist in the fight against Shadow and rescuing Coco and Nuts.

A direct continuation of the former season, this series again follows the story of Nozomi Yumehara and her friends from Precure 5. The girls who had formerly lost their powers and bade farewell to their friends Coco and Nuts from Palmier Kingdom are resurrected as Pretty Cure by the mysterious woman Flora who also wants them to find her in a place called Cure Rosegarden. To go there, they need the magic Rose Pact and the powers of the four kings of countries surrounding Palmier. But a dark organization called Eternal is also striving to get to Cure Rosegarden by stealing the Rose Pact. Luckily, Precure get helped by new allies: the delivery-boy Syrup who can change into a giant bird and fly them anywhere they want and the mysterious and beautiful fighter Milky Rose stand alongside Pretty Cure to protect what is really valuable.

It's Nozomi's birthday, but it is disturbed by Bunbee chasing after a girl from another world, Chocola. When Pretty Cure rescue her, she thanks them by taking them to her country, Dessert Kingdom. In this cockaigne with rivers of juice and candy growing on trees, they feel very comfortable. But then they meet the evil Mushiban and his two subordinates Dry and Bitter. They want to take over the kingdom and change Pretty Cure into sweets. In order to save not only Nozomi's Birthday but also the whole Dessert Kingdom, Pretty Cure have to fight their way against Dry and Bitter and also against their own friend: Coco, who is being brainwashed by Mushiban.