Dante is a mercenary specializing in paranormal cases, preferring those that call for demon slaying. He is muscular, has white/silver hair, icy-blue eyes and is usually seen wearing red dusters/trench coats. Dante's arsenal usually consists of firearms and melee weapons, including "Ebony and Ivory", twin handguns that never need reloading, as well as a variety of swords such as the "Rebellion" and "Force Edge", Devil Arms created by his father. The guns are handmade with "For Tony Redgrave, By.45 Art Warks" written on them (Tony Redgrave is the alias used by Dante). He possesses superhuman strength and agility, as a result of his half-demon heritage. This gives him the ability to enter a heightened state called "Devil Trigger". In this state, Dante possesses greater strength and speed, his health regenerates at a steady pace, and further abilities with his equipped melee weapon, including flight. Dante is confident in his encounters with opponents, and frequently taunts boss characters before battling them. With the exception of Devil May Cry 4, Dante says the phrase "Devils never cry" in every game, implying that no matter how much of a demon he may prove to be, his ability to cry makes his human side precious to him.

Dante is one of the twin sons of Sparda, the demon knight who sided with humanity and drove back an invasion of the human world by demons 2,000 years ago. After Sparda's death, Dante and his identical twin brother Vergil were raised by their human mother, Eva. When Dante and Vergil were children, the family was attacked by demons, resulting in Eva's death. This event led to Dante's commitment to hunting demons in pursuit of those that killed his mother.

Solid Snake (real name David, commonly referred to as Snake, and later referred to as Old Snake), was a former spy, special operations soldier and mercenary. He was a product of the Les Enfants Terribles project and "son" of legendary soldier, Big Boss, along with his "brothers" Liquid Snake and Solidus Snake.

Possessing an IQ of 180 and fluent in six languages, including English and French, he was known as "the man who makes the impossible possible" and his exploits made him into a living legend among the military black ops.

Notorious for his cruel and deceitful fighting ability, Hisoka has proven to be deadly. His deviousness and volatility has made many opponents have difficulty anticipating his next move, and this has led to him winning many battles. Using Shu powered poker cards as his primary weapon, he throws them with ease and deadly accuracy.

Also, he is very intrigued by Gon and the potential this young boy has to become an adept and powerful adversary. Hisoka, ever looking for a strong opponent, is willing to aid, or at least not defeat prematurely, someone that could develop into a future opponent.

Aizen spent much of his career in the 5th Division, eventually becoming its lieutenant under the former captain, Shinji Hirako. Shinji kept Aizen under his view during this time because he felt there was something dangerous about him. 100 years ago, Aizen's experiments on Soul Reaper/hollow hybrids involved using an unknown method to cause spirits to transform into hollows, eventually culminating in the creation of the Visoreds. He framed Urahara for the hollowfication process and forced him to leave Soul Society.
During that time, Aizen met Gin Ichimaru and Kaname Tōsen, and lured them to his side. Aizen became captain of the 5th Division later on, and Ichimaru became his lieutenant and right hand man. Ichimaru and Tōsen later became captains of the 3rd and 9th Divisions, respectively, but remained loyal only to Aizen.The principal antagonist of the series, he resides in Hueco Mundo together with Ichimaru and Tōsen, commanding an army of Arrancar and Hollows, his ultimate goal being to overthrow Soul Society along with the Soul King and take his place as god of the world.