Guts is the protagonist of the story. A tall, muscular male with a huge sword called the Dragon Slayer, a prosthetic left forearm that has a magnetic grip, and also conceals a cannon. Guts is a tragic hero; he is born as one who may be able to struggle against Causality, but seemingly unable to affect it on a large scale.

The secret weapon of the Hellsing organization, Alucard is a vampire, specializing in killing other vampires. At first glance he seems to be nothing but a rather odd gunman, but when he truly unleashes his powers, it becomes quite clear that he is not a mortal.After walking the night for half a millennium, he is constantly seeking a worthy opponent, and with his powers of regeneration, strength, and shape-shifting, not to mention his army of familiars, he lays waste to any of his master's enemies.However, beneath his cool and heartless exterior lurks a dark and tragic past, and a longing for the only thing an immortal can never have.